Use of estrogen antagonists and estrogen agonists in...

A - Human Necessities – 61 – K

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A61K 31/395 (2006.01) A61K 31/40 (2006.01) A61K 31/4439 (2006.01) A61K 31/4453 (2006.01) A61K 31/4725 (2006.01)

Patent

CA 2198578

Disclosed is a pharmaceutical composition for inhibiting pathological conditions related to organ systems which respond to estrogen agonists in a mammal. The composition comprises an effective amount of a compound of formula I (see fig.I) (wherein A is CH2 or NR; R is H or alkyl; B, E and D are each CH or N; Y is a cyclic group such as phenyl; Z1 is a divalent group such as -OCH2CH2-; G is an optionally substituted amino such as piperidino or pyrrolidino; and e is 0, 1 or 2).

Composition pharmaceutique pour traiter les troubles biologiques liés à des systèmes organiques qui réagissent à des agonistes de l'oestrogène chez les mammifères. La composition renferme une quantité efficace d'un composé de formule I (voir fig. I) ¢où A est CH2 ou NR; R est H ou un alkyle; B, D et E sont chacun CH ou N; Y est un groupe cyclique comme le phényle; Z1 est un groupe divalent comme -OCH2CH2; G est un groupe amino avec substitution facultative, comme un pipéridino ou un pyrrolidino; e est 0, 1 ou 2!.

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