Enantioselective process for thiazole intermediates

Details Enantioselective process for thiazole intermediates Enantioselective process for thiazole intermediates

C - Chemistry, Metallurgy

07

D

C07D 277/24 (2006.01) C07D 417/04 (2006.01) C07F 5/02 (2006.01)

Patent

CA 2167287

An enanthioselective process for preparing the compounds of for- mulas (I) and (II) from the prochi- ral ketone precursor of the alcohol of formula (I). The compounds of for- mulas (I) and (II) are thus obtained in substantially enantiomerically pure form by reducing the ketone with a borane reducing agent in the presence of a chiral oxazaborolidine catalyst.

Procédé énantiosélectif servant à la préparation des composés représentés par les formules (I) et (II) à partir du précurseur de cétone prochirale de l'alcool représenté par la formule (I). De ce fait, on obtient les composés correspondants aux formules (I) et (II) sous une forme sensiblement pure énantiomériquement par réduction de la cétone avec un agent réducteur de borane en présence d'un catalyseur d'oxazaborolidine chirale.

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