Pharmaceutical compositions with enhanced performance

Details Pharmaceutical compositions with enhanced performance Pharmaceutical compositions with enhanced performance

A - Human Necessities

61

K

A61K 9/16 (2006.01) A61K 9/14 (2006.01) C08B 13/00 (2006.01)

Patent

CA 2568007

Disclosed are polymers of hydroxypropyl methyl cellulose acetate succinate (HPMCAS) and hydroxypropyl methyl cellulose acetate (HPMCA) with unique degrees of substitution of hydroxypropoxy, methoxy, acetyl, and succinoyl groups. When used in making compositions comprising a low-solubility drug and such polymers, the polymers provide enhanced aqueous concentrations and/or improved physical stability.

Cette invention concerne des polymères d'hydroxypropyl méthyl cellulose acétate succinate (HPMCAS) de d'hydroxypropyl méthyl cellulose acétate (HPMCA) présentant des degrés uniques de substitution des groupes hydroxypropoxy, méthoxy, acétyle, and succinoyle. Lorsqu'ils entrent dans la fabrication de compositions conjointement avec un médicament à faible solubilité, ces polymères autorisent des concentrations aqueuses plus marquées et/ou une stabilité physique améliorée.

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