Phenoxyphenyl cyclopentenyl hydroxyureas

Details Phenoxyphenyl cyclopentenyl hydroxyureas Phenoxyphenyl cyclopentenyl hydroxyureas

C - Chemistry, Metallurgy

07

C

C07C 275/64 (2006.01) A61K 31/17 (2006.01)

Patent

CA 2169066

Certain novel phenylsubstituted cyclopentenylhydroxyurea compounds having the ability to inhibit the 5-lipoxygenase enzyme and being the formula (II) isomers of the compounds having formula (II) and the pharmaceutically acceptable salts thereof, wherein R1 is hydrogen, fluoro or chloro; and R2 is hydrogen or methyl. These compounds are useful in the prevention, treatment or alleviation of inflammatory diseases, allergy and cardiovascular diseases in mammals, and as the active ingredient in pharmaceutical compositions for treating such conditions.

Certains nouveaux composés de cyclopenténylhydroxyurée à substitution phényle ont la faculté d'inhiber la 5-lipoxygenase et sont les isomères dextrogyres des composés ayant la formule (II), et de leurs sels pharmaceutiquement acceptables. Dans cette formule, R1 est hydrogène, fluoro ou chloro; et R2 est hydrogène ou méthyle. Ces composés sont utiles dans la prévention, le traitement ou l'atténuation des maladies inflammatoires, de l'allergie et des maladies cardiovasculaires chez les mammifères, et comme principe actif dans des compositions pharmaceutiques permettant de traiter de telles affections.

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