C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 231/56 (2006.01) A61K 31/415 (2006.01) A61P 13/00 (2006.01) A61P 25/00 (2006.01) A61P 29/00 (2006.01)
Patent
CA 2712403
The present invention relates to novel 1-benzyl-3-hydroxymethylindazole derivatives according to Formula (I) described in the claims, and to a pharmaceutical composition comprising them, together with a pharmaceutically acceptable vehicle. In addition, the present invention relates to the use of 1-benzyl-3- hydroxymethylindazole derivatives for the preparation of a pharmaceutical composition that is active in the treatment of diseases based on the expression of MCP-1, CX3CR1 and p40, and to their use in a method for treating or preventing diseases based on the expression of MCP-1, CX3CR1 and p40.
La présente invention concerne de nouveaux dérivés de 1-benzyl-3-hydroxyméthylindazole selon la formule (I) décrite dans les revendications et une composition pharmaceutique les comprenant, conjointement à un véhicule pharmaceutiquement acceptable. De plus, la présente invention concerne lutilisation de dérivés de 1-benzyl-3-hydroxyméthylindazole pour la préparation dune composition pharmaceutique qui est active dans le traitement des maladies basées sur lexpression de MCP-1, CX3CR1 et p40 et leur utilisation dans un procédé permettant de traiter ou de prévenir les maladies basées sur lexpression de MCP-1, CX3CR1 et p40.
Cazzolla Nicola
Furlotti Guido
Garofalo Barbara
Guglielmotti Angelo
Mangano Giorgina
Aziende Chimiche Riunite Angelini Francesco A.c.r.a.f. S.p.a.
Riches Mckenzie & Herbert Llp
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