Quinolinecarboxylic acid derivative or salts thereof

Details Quinolinecarboxylic acid derivative or salts thereof Quinolinecarboxylic acid derivative or salts thereof

C - Chemistry, Metallurgy

07

D

C07D 401/14 (2006.01) A61K 31/4709 (2006.01) A61P 31/04 (2006.01)

Patent

CA 2376760

This invention relates to 1-(6-Amino-3,5-difluoropyridin-2- yl)-8-bromo-7-(3-ethylaminoazetidin-1-yl)-6-fluoro-4-oxo-1,4- dihydroquinoline-3-carboxylic acid represented by the formula: Image or a salt thereof, and also to a medicine containing the same. This compound has characteristic features that, when administered orally, it has extremely high blood half-life and bioavailability while retaining properties that is has extremely high antimicrobial effects and has low toxicity. It can be used widely as preventives, therapeutics and the like for various infectious diseases of human and animals.

L'invention concerne un acide 1-(6-amino-3,5-difluoropyridine-2-yl)-8-bromo-7-(3-éthylaminoazétidine-1-yl)-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylique ou ses sels et les médicaments contenant l'acide ou ses sels. Ce composé est caractérisée en ce qu'il fait preuve, après administration orale, d'une longue demi-vie dans le sang tout en ayant un effet antibactérien extrêmement important, une biodisponibilité extrêmement élevée et une faible toxicité. Ainsi, il est indiqué comme préventif ou remède pour différentes maladies infectieuses chez les humains et les animaux.

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