Use of platelet-derived growth factor to improve collateral...

Details Use of platelet-derived growth factor to improve collateral... Use of platelet-derived growth factor to improve collateral...

A - Human Necessities

61

K

A61K 38/18 (2006.01) C07K 14/49 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2161669

The present invention provides a noninvasive method for improving collateral circulation to tissue at risk of ischemia or ischemic necrosis. Improved collateral circulation is obtained by applying a growth factor from the PDGF family to the area at or around an occluded blood vessel causing compromised direct circulation to the affected tissue. The present invention further provides a method for anastomosing one or more divided blood vessels using a growth factor from the PDGF family. Preferably, the growth factor is a administered locally to the end(s) of the divided blood vessel(s) at or around the area where a single divided blood vessel is attached to tissue of an organ at risk of ischemia.

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