Neuroprotective indolone and related derivatives

Details Neuroprotective indolone and related derivatives Neuroprotective indolone and related derivatives

C - Chemistry, Metallurgy

07

D

C07D 401/06 (2006.01) A61K 31/435 (2006.01) C07D 413/06 (2006.01) C07D 417/06 (2006.01) C07D 419/06 (2006.01) C07D 451/04 (2006.01) C07D 451/06 (2006.01)

Patent

CA 2080475

Disclosed are 5-(1-hydroxy-2-piperidinopropyl)- 2(1H,3H)-indolone derivatives and analogs of the formula: (see formula I) (wherein A is a group for completing a ring; X is O, S or (CH2)m in which m is 0-6; R2 is H, or alkyl; R3 and R4 are each H or together ethylene; and Z1 is H, alkyl, alkoxy or halo); pharmaceutical compositions thereof; methods of treating CNS disorders therewith; and intermediates useful in the preparation of said compounds.

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