Pyrazolo`4,3-d.pyrimidinone compounds as cgmp pde inhibitors

Details Pyrazolo`4,3-d.pyrimidinone compounds as cgmp pde inhibitors Pyrazolo`4,3-d.pyrimidinone compounds as cgmp pde inhibitors

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/505 (2006.01) A61K 31/522 (2006.01) A61P 3/00 (2006.01) A61P 15/00 (2006.01) A61P 25/00 (2006.01) C07D 231/00 (2006.01) C07D 239/00 (2006.01)

Patent

CA 2436911

Compounds of general formula (I), or pharmaceutically or veterinarily acceptable salts, solvates, polymorphs or pro-drugs thereof wherein: wherein R1, R2, R3, R4, X and A have the meanings given herein which are useful in the curative and prophylactic treatment of a medical condition for which inhibition of a cyclic guanosine 3',5'-monophosphate phosphodiesterase (e.g. cGMP PDE5) is desired.

L'invention concerne des composés représentés par la formule générale (I), ou des sels, des solvates, des polymorphes ou des promédicaments de ces composés, acceptables sur les plans vétérinaire et pharmaceutique, dans laquelle R?1¿, R?2¿, R?3¿, R?4¿, X et A possèdent les significations mentionnées, et qui sont utiles dans le traitement curatif ou prophylactique de troubles médicaux pour lesquels on recherche une inhibition d'une guanosine 3',5'-monophosphate phosphodiestérase cyclique (par exemple la GMPc PDE5).

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