Alk7 and myostatin inhibitors and uses thereof

Details Alk7 and myostatin inhibitors and uses thereof Alk7 and myostatin inhibitors and uses thereof

A - Human Necessities

61

K

A61K 38/17 (2006.01) A61P 21/06 (2006.01)

Patent

CA 2558478

The invention relates to ALK7 soluble receptors and their uses as antagonists of the function of certain ligands such as GDF-8 (Myostatin) and GDF- 11. The ALK7 soluble receptor of the invention is useful as antagonists of GDF-8 and GDF-11 in the treatment of neuronal diseases or conditions such as stroke, spinal cord injury, and all peripheral nerve diseases. The ALK7 soluble receptor of the invention is also useful as GH (growth hormone) equivalent, and for increasing muscle mass.

L'invention concerne des récepteurs soluble d'ALK7 et leurs utilisations comme antagonistes de la fonction de certains ligands, tels que GDF-8 (myostatine) et GDF- 11. Le récepteur soluble d'ALK7 de l'invention est utile comme antagoniste de GDF-8 et de GDF-11 dans le traitement de maladies ou affections neuronales, telles que l'accident vasculaire cérébral, le traumatisme médullaire, et toutes les maladies du nerf périphérique. Le récepteur soluble d'ALK7 de l'invention est également utile comme équivalent de l'hormone de croissance, ainsi que pour augmenter la masse musculaire.

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