Novel glycosidase inhibitors and their pharmacological uses,...

Details Novel glycosidase inhibitors and their pharmacological uses,... Novel glycosidase inhibitors and their pharmacological uses,...

A - Human Necessities

61

K

A61K 31/70 (2006.01) A61K 31/00 (2006.01) A61K 31/13 (2006.01) A61K 31/131 (2006.01) A61K 31/16 (2006.01) A61K 31/198 (2006.01) A61K 31/27 (2006.01) A61K 31/715 (2006.01) A61K 38/47 (2006.01) A61P 3/00 (2006.01) A61P 3/06 (2006.01) A61P 3/08 (2006.01) A61P 3/10 (2006.01)

Patent

CA 2395305

The invention concerns the use of a polyamine derivative or a polyamine for inhibiting the active site of glycosidase enzymes intervening in the transformation of polysaccharides into sugars, in particular into glucose, in a living organism and the use of a polyamine derivative for preparing a medicine for diagnosing, preventing or treating pathologies involving metabolic disorders related to glycosidases, and more particularly a dysfunction of intestinal absorption of glucose, such as non-insulin-dependent diabetes, obesity, hyperglycaemia, or hyperlipidemia.

L'invention a pour object l'utilisation d'un dérivé de polyamine ou d'une polyamine pour inhibir le site actif des enzymes glycosidases intervenant dans la transformation de polysaccharides en sucres, notamment en glucose, dans un organisme vivant et l'utilisation d'un dérivé de polyamine ou d'une polyamine pour la préparation d'un medicament destiné au diagnostic, à la prévention ou au traitement de phathologies inpliquant des désordres métaboliques liés aux glycosidases, et plus particulièrement une dérégulation de l'absorption intestinale de glucose, telles que le diabète non-insulino dépendant, l'obésité, l'hyperglycémie, ou l'hyperlipidémie.

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