C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 7/06 (2006.01) C07K 5/10 (2006.01) A61K 38/06 (2006.01) A61K 38/07 (2006.01) A61K 38/08 (2006.01) A61P 25/00 (2006.01)
Patent
CA 2581564
The invention relates to compounds that inhibit thyrotropin-releasing hormone (TRH)- degrading ectoenzyme and/or enhance, and/or mimic the biological actions of TRH. The compounds find therapeutic application, particularly in conditions involving neuronal cell injury and disturbances in neurobiological function. These compounds are based on a C-terminally extended TRH-structure, wherein the C-terminal extension mainly consists of (D) amino acids.
L'invention concerne des composés qui inhibent l'ectoenzyme dégradant l'hormone de libération de la thyrotropine (TRH) et/ou renforcent, et/ou imitent les actions biologiques de TRH. Ces composés ONT une application thérapeutique, notamment dans des états qui impliquent une lésion de cellules neuronales et des perturbations au niveau de la fonction neurobiologique.
Gowling Lafleur Henderson Llp
The Provost Fellows And Scholars Of The College Of The Holy And Undivid Ed T
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