C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/241.4
C07D 223/16 (2006.01)
Patent
CA 2014046
(ABSTRACT) SUMMARY OF THE DESCRIPTION The invention concerns 1-phenyl-N-/2-chlorethyl- carbamoyl/-7,8-dimethoxy-2,3,4,5-tetrahydro,-1H-3- benzazepins racemate and optically active isomers with formula 2 and method for their preparation. Image The compounds with formula 2 show high inhibiting effect on dopamine and noradrenaline uptake, and the most active is the right rotating isomer /+/-2. The racemic 2 possesses moderate untiulcer activity in experimental model of stress induced stomach ulcers in rats. The left rotating isomer /-/-2 shows direct cytostatic effect on tumour cells from ascite tumour of Erlich /ATE/ and leucosis L1210.
Angelova Ivanka G.
Ivanov Chavdar B.
Ivanova Nedyalka S.
Maneva Katerina M.
Mondeshka Donka M.
Angelova Ivanka G.
Ivanov Chavdar B.
Ivanova Nedyalka S.
Maneva Katerina M.
Mondeshka Donka M.
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