Porous ceramic/porous polymer layered scaffolds for the...

A - Human Necessities – 61 – L

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A61L 27/40 (2006.01) A61L 27/10 (2006.01) A61L 27/14 (2006.01) A61L 27/38 (2006.01) A61L 27/42 (2006.01) A61L 27/44 (2006.01) A61L 27/56 (2006.01)

Patent

CA 2391464

A composite scaffold with a porous ceramic phase and a porous polymer phase. The polymer is foamed while in solution that is infused in the pores of the ceramic to create a interphase junction of interlocked porous materials. The preferred method for foaming is by lyophilization. The scaffold may be infused or coated with a variety of bioactive materials to induce ingrowth or to release a medicament. The multi-layered porous scaffold can mimic the morphology of an injured tissue junction with a gradient morphology and cell composition, such as articular cartilage.

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