C - Chemistry – Metallurgy – 08 – B
Patent
C - Chemistry, Metallurgy
08
B
C08B 37/08 (2006.01) A61L 24/04 (2006.01) A61L 27/20 (2006.01) A61L 31/04 (2006.01)
Patent
CA 2339066
An amide of hyaluronic acid or a derivative thereof which comprises at least one repetitive unit of general formula (I): wherein R = NR6R7, or alcoholic group of the aliphatic, aromatic, arylaliphatic, cycloaliphatic, heterocyclic series, OH, O-, alcoholic group of hyaluronic acid, amino group of deacylated hyaluronic acid; R1, R2, R3, R4 = H, SO3-, acyl group derived from a carboxylic acid of the aliphatic, aromatic, arylaliphatic, cycloaliphatic, heterocyclic series, -CO- (CH2)2-COOY; Y = negative charge, or H; R5 = -CO- CH3, H, SO3-, acyl group derived from a carboxylic acid of the aliphatic, aromatic, arylaliphatic, cycloaliphatic, heterocyclic series, acylic group of hyaluronic acid; R6 = is H or a aliphatic, aromatic, arylaliphatic, cycloaliphatic, or heterocyclic group, substituted or unsubstituted; R7 = is H or an aliphatic, aromatic, arylaliphatic, cycloaliphatic, or heterocyclic group, substituted or unsubstituted; wherein at least one of R or R5 forms an amide group.
Un amide d'acide hyaluronique ou un dérivé de celui-ci, qui comprend au moins un motif de répétition de formule générale (I), dans laquelle R = NR¿6?R¿7?, ou groupe alcoolique de la série aliphatique, aromatique, arylaliphatique, cycloaliphatique, hétérocyclique, OH, O-, groupe alcoolique d'acide hyaluronique, groupe amino d'acide hyaluronique désacylé; R¿1?, R¿2?, R¿3?, R¿4? = H, SO¿3?-, groupe acyle dérivé d'un acide carboxylique de la série hétérocyclique, cycloaliphatique, arylaliphatic, aromatique, aliphatique, -COC- (CH¿2?)¿2?-COOY; Y = charge négative ou H ; R¿5? = -CO-CH¿3?, H, SO¿3?-, groupe acyle, dérivé d'un acide carboxylique de la série hétérocyclique, cycloaliphatique, arylaliphatique, aromatique, aliphatique, groupe acyclique d'acide hyaluronique; R¿6? = H ou un groupe hétérocyclique, cycloaliphatique, arylaliphatique, aromatique ou aliphatique, substitué ou non; R¿7? = H ou un groupe hétérocyclique, cycloalipahtique, arylaliphatique, aromatique, aliphatique, substitué ou non. Au moins R ou R¿5? formant un groupe amide.
Bellini Davide
Topai Alessandra
Fidia Advanced Biopolymers S.r.l.
Fidia Farmaceutici S.p.a.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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