Anti-sepsis conjugate vaccine

Details Anti-sepsis conjugate vaccine Anti-sepsis conjugate vaccine

A - Human Necessities

61

K

A61K 47/48 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2406229

The present invention provides an immunogenic conjugate comprising polysaccharides derived from biologically deacylated gram-negative bacterial moieties linked to D. discoideum proteinase 1, as well as novel subunits thereof, and methods of making and using the conjugates in vaccines to treat sepsis and other infectious complications.

La présente invention concerne un conjugué immunogénique renfermant des polysaccharides dérivés de fractions bactériennes gram-négatives biologiquement désacylées, liées à une protéinase 1<i>D. discoideum</i>, ainsi que des nouvelles sous-unités de ceci et des procédés de préparation et d'utilisation de ces conjugués dans des vaccins destinés à traiter la spesie et d'autres complications infectieuses.

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