A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/44 (2006.01) A61K 9/107 (2006.01) A61K 9/48 (2006.01) A61K 31/365 (2006.01) A61K 47/18 (2006.01)
Patent
CA 2294033
The present invention provides a novel pharmaceutical composition based on the use of a particular amount of basic amine which comprises a pyranone compound as a pharmaceutically active agent, a basic amine in an amount of from about 0.1 % to about 10 % by weight of the total composition, one or more pharmaceutically acceptable solvents, and one or more pharmaceutically acceptable surfactants. In addition, the composition may further comprise one or more pharmaceutically acceptable oils. The composition is in a form of self-emulsifying formulation which provides high concentration and high oral bioavailability for lipophilic pyranone compounds.
La présente invention concerne une nouvelle composition pharmaceutique basée sur l'utilisation d'une certaine quantité d'une amine basique, cette composition renfermant: un composé pyrone en tant qu'agent pharmaceutiquement actif; une quantité d'amine basique variant environ entre 0,1 % et 10 % en poids de la composition totale; un ou plusieurs solvants pharmaceutiquement acceptables; et un ou plusieurs tensioactifs pharmaceutiquement acceptables. Cette composition, qui peut en outre renfermer une ou plusieurs huiles pharmaceutiquement acceptables, se présente sous la forme d'une formulation autoémulsifiante présentant une concentration élevée en composés pyrones lipophiles et une biodisponibilité orale importante pour ces derniers.
Gao Ping
Morozowich Walter
Macrae & Co.
Pharmacia & Upjohn Company
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