Process for preparing cross-bridged tetraaza macrocycles

Details Process for preparing cross-bridged tetraaza macrocycles Process for preparing cross-bridged tetraaza macrocycles

C - Chemistry, Metallurgy

07

D

C07D 487/08 (2006.01) B01J 31/18 (2006.01) C07D 255/00 (2006.01) C07F 13/00 (2006.01)

Patent

CA 2348893

The present invention relates to a process for preparing a cross-bridged tetraaza macrocyclic ligand having formula (I) wherein each R is independently C1-C8 linear or branched alkyl, -(CH2)xCO2M, and mixtures thereof; provided both of the R units are not methyl; M is hydrogen or a salt forming cation; x is from 1 to 6; each index n is independently from 0 to 3; by contacting a di- quaternary cis tetracycle precursor with hydrogen in the presence of a palladium catalyst in an aqueous solution having a pH of at least about 10 at a temperature of about 40 ~C to about 100 ~C.

La présente invention concerne un procédé de préparation d'un ligand tétraaza macrocyclique de formule (I) dans laquelle chaque R est, de manière indépendante, un alkyle linéaire C¿1?-C¿8? ou un alkyle ramifié (CH¿2?)¿x?CO¿2?M, et des mélanges de ce ligand, pourvu que les deux R ne soient pas des groupes méthyle, M est un hydrogène ou un cation formant un sel, x prend les valeurs de 1 à 6, chaque indice n prend, de manière indépendante, les valeurs de 1 à 3. Ce procédé consiste à mettre en contact un précurseur tétracyclique cis di-quaternaire avec de l'hydrogène en présence d'un catalyseur au palladium dans une solution aqueuse de pH au moins égal à environ 10 et à une température comprise entre environ 40 ·C et environ 100·C.

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