C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/12 (2006.01) A61K 31/423 (2006.01) A61K 31/428 (2006.01) A61K 31/4439 (2006.01) A61P 3/10 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01)
Patent
CA 2743489
Described herein are substituted bicyclic amines. In particular, described herein are substituted bicyclic amines that are effective as antagonists of SSTR5 and useful for the treatment, control or prevention of disorders responsive to antagonism of SSTR5, such as type 2 diabetes, insulin resistance, lipid disorders, obesity, atherosclerosis, metabolic syndrome, depression, and anxiety.
L'invention porte sur des amines bicycliques substituées. En particulier, l'invention porte sur des amines bicycliques substituées qui sont efficaces en tant qu'antagonistes de SSTR5 et utiles pour le traitement, la régulation ou la prévention daffections sensibles à un antagonisme de SSTR5, tels que le diabète de type 2, une résistance à l'insuline, des troubles lipidiques, l'obésité, l'athérosclérose, le syndrome métabolique, la dépression et l'anxiété.
Bawiec John
He Jiafang
Liang Gui-Bai
Liu Weiguo
Yang Lihu
Merck Sharp & Dohme Corp.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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