N-substituted 2-cyanopyrrolidines

Details N-substituted 2-cyanopyrrolidines N-substituted 2-cyanopyrrolidines

C - Chemistry, Metallurgy

07

D

C07D 207/16 (2006.01) A61K 31/40 (2006.01) A61K 31/44 (2006.01) A61K 31/505 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01)

Patent

CA 2269810

N-(N'-substituted glycyl)-2-cyanopyrrolidines, e.g. the compounds of formula (I) wherein R has various significances, are novel. They inhibit DPP-IV (dipeptidyl-peptidase-IV) activity. They are therefore indicated for use as pharmaceuticals in inhibiting DPP-IV and in the treatment of conditions mediated by DPP-IV, such as non-insulin-dependent diabetes mellitus, arthritis, obesity, osteoporosis and further conditions of impaired glucose tolerance.

L'invention concerne des N-(à substitution N' glycyl)-2-cyanopyrrolidines nouvelles, par exemple des composés de formule (I), dans laquelle R a différentes significations. Elles inhibent l'activité DPP-IV (dipeptidyl-peptidase IV) et sont donc indiquées pour être utilisées comme médicaments servant à inhiber DPP-IV et à traiter des états engendrés par DPP-IV, tels que le diabète non-insulinodépendant, l'arthrite, l'obésité, l'ostéoporose et d'autres états dans lesquels la tolérance au glucose est perturbée.

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