Penumbra nucleic acid molecules, proteins and uses thereof

Details Penumbra nucleic acid molecules, proteins and uses thereof Penumbra nucleic acid molecules, proteins and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A01K 67/027 (2006.01) A61K 38/17 (2006.01) C07K 14/705 (2006.01) C12N 5/10 (2006.01) C12Q 1/68 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2623901

The present invention relates to murine and human Penumbra (for proerythroblast nu[new] membrane) nucleic acid molecules, proteins and the uses thereof. The invention further relates to the use of Penumbra molecules for the detection of 7q31q32-related deletions, including such deletions associated with myeloid malignancies, particularly detection by hybridization using Penumbra-based probes.

L'invention se rapporte à des molécules d'acide nucléique et à des protéines de Penumbra ("proerythroblastnu[new] membrane" ou nouvelle membrane de proérythroblaste) murines et humaines, et aux utilisations de ces dernières. L'invention porte sur l'utilisation des molécules de Penumbra dans la détection de délétions liées à 7q31q32, y compris des délétions associées aux tumeurs malignes myéloïdes, en particulier la détection par hybridation au moyen de sondes basées sur Penumbra.

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