Atp analogues

Details Atp analogues Atp analogues

C - Chemistry, Metallurgy

07

H

C07H 19/20 (2006.01) A61K 31/675 (2006.01) A61K 31/70 (2006.01) C07D 473/00 (2006.01) C07F 9/38 (2006.01) C07F 9/547 (2006.01)

Patent

CA 2107667

2107667 9217488 PCTABS00016 There are disclosed compounds of formula (I), wherein Q represents CR1R2, R represents O or CR3R4, W represents O or CH2, R1, R2, R3 and R4 independently represent hydrogen or halogen, X represents S(O)nR5, alkyl C1-6, alkoxy C1-6, acylamino C1-6, CONR6R7, NR8R9, halogen, a 5- or 6-membered S containing heterocycle, or phenyl optionally substituted by alkyl C1-6, n represents 0, 1 or 2, R5 represents aryl or alkyl C1-6 optionally substituted by one or more substituents selected from hydroxy, alkoxy C1-6, halogen and aryl; R6, R7, R8 and R9 independently represent hydrogen or alkyl C1-6, Y represents NH2 or alkoxy C1-6, and Z represents an acidic moiety, in addition, when R represents CR3R4, then -Q-Z may also represent hydroxy or -OP(O) (OH)2, and pharmaceutically acceptable salts thereof, with certain provisos, for use as pharmaceuticals.

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