New process for the preparation of retiferol derivatives

Details New process for the preparation of retiferol derivatives New process for the preparation of retiferol derivatives

C - Chemistry, Metallurgy

07

C

C07C 403/08 (2006.01) C07C 45/29 (2006.01) C07C 45/69 (2006.01) C07C 69/013 (2006.01) C07F 7/10 (2006.01) C07F 7/18 (2006.01) C12P 7/62 (2006.01) C12P 23/00 (2006.01)

Patent

CA 2323311

New Process for the Preparation of Retiferol Derivatives The invention is concerned with a new process for the preparation of retiferol derivatives of formula I: Image wherein A is -C =C- or -CH=CH-, and R1 and R2 are independently of each other lower alkyl or lower perfluoroalkyl, by method A) which comprises the coupling of ketones of formula II with compounds of formula III or by method B) which comprises the coupling of phosphinoxides of formula IV with aldehydes of formula V Compounds of formula I are useful in the treatment or prevention of hyperproliferative skin diseases, particularly psoriasis, basal cell carcinomas, disorders of keratinization and keratosis; or for reversing the conditions associated with photodamage.

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