C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 31/7088 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61K 45/00 (2006.01) A61K 48/00 (2006.01) A61P 37/00 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2442777
The present invention relates to human secreted polypeptides, and isolated nucleic acid molecules encoding said polypeptides, useful for diagnosing and treating immune disorders and diseases. Antibodies that bind these polypeptides are also encompassed by the present invention. Also encompassed by the invention are vectors, host cells, and recombinant and synthetic methods for producing said polynucleotides, polypeptides, and/or antibodies. The invention further encompasses screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further encompasses methods and compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.
La présente invention concerne des polypeptides sécrétés par l'être humain et des molécules d'acide nucléique isolées codant lesdits polypeptides, permettant de diagnostiquer et de traiter des troubles et des maladies immunitaires. L'invention se rapporte également à des anticorps se fixant à ces polypeptides. L'invention concerne en outre des vecteurs, des cellules hôtes ainsi que des méthodes de recombinaison et de synthèse permettant de produire lesdits polynucléotides, polypeptides et/ou anticorps. Par ailleurs, l'invention a trait à des méthodes de criblage destinées à identifier des agonistes et des antagonistes desdits polynucléotides et polypeptides. La présente invention se rapporte en outre à des méthodes et des compositions permettant d'inhiber ou d'améliorer la production et la fonction desdits polypeptides.
Rosen Craig A.
Ruben Steven M.
Human Genome Sciences Inc.
Mbm Intellectual Property Law Llp
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