Peptides which target tumor and endothelial cells,...

Details Peptides which target tumor and endothelial cells,... Peptides which target tumor and endothelial cells,...

A - Human Necessities

61

K

A61K 38/10 (2006.01) A61K 38/08 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01)

Patent

CA 2506813

The present invention relates generally to peptide analogs of Ac-PHSCN-NH2 which target tumor and endothelial cells and have anti-tumor, anti-angiogenic and anti-metasastic activity, methods of making these peptides, compositions thereof and methods of using these peptides and pharmaceutical compositions thereof to treat, prevent and detect diseases characterized by tumor growth, metastasis and angiogenesis. The peptide analogs may serve,inter alia, as carriers of radioactivity, PET-active compounds, toxins, fluorescent molecules and PEG molecules.

L'invention concerne en général des analogues peptidique de Ac-PHSCN-NH¿2 ?qui ciblent des cellules endothéliales et tumorales et possèdent une activité antitumorale, antiangiogénique et antimétastasique. L'invention porte également sur des procédés de fabrication desdits peptides, sur des compositions comprenant lesdits peptides, ainsi que sur des méthodes d'utilisation desdits peptides et sur des compositions pharmaceutiques les comprenant, pour traiter, prévenir et détecter des maladies caractérisées par une croissance tumorale, la métastase et l'angiogénèse. Ces analogues peptidiques peuvent servir, entre autres, de porteurs de radioactivité, de composés actifs en PET, de toxines, de molécules fluorescentes et de molécules PEG.

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