Pyrimidines and triazines as integrin antagonists

Details Pyrimidines and triazines as integrin antagonists Pyrimidines and triazines as integrin antagonists

C - Chemistry, Metallurgy

07

D

C07D 239/48 (2006.01) A61K 31/505 (2006.01) C07D 239/42 (2006.01) C07D 239/46 (2006.01) C07D 239/95 (2006.01) C07D 251/18 (2006.01) C07D 403/06 (2006.01) C07D 487/04 (2006.01)

Patent

CA 2333927

This invention relates to novel heterocycles which are useful as antagonists of the .alpha.v.beta.3 integrin, the .alpha.2b.beta.3 integrin, and related cell surface adhesive protein receptors, to pharmaceutical compositions containing such compounds, processes for preparing such compounds, and to methods of using these compounds, alone or in combination with other therapeutic agents, for the inhibition of cell adhesion, the treatment of angiogenic disorders, inflammation, bone degradation, cancer metastasis, diabetic retinopathy, thrombosis, restenosis, macular degeneration, and other conditions mediated by cell adhesion and/or cell migration and/or angiogenesis.

Cette invention, qui a trait à de nouveaux composés hétérocycliques se révélant des plus utiles en tant qu'antagonistes de l'intégrine .alpha.¿v?.beta.¿3?, de l'intégrine .alpha.¿2b?.beta.¿3? et de récepteurs de protéines adhérant à la surface cellulaire connexes, concerne également des compositions pharmaceutiques renfermant ces composés, des procédés de production de ces composés ainsi que des méthodes d'utilisation desdits composés, seuls ou associés à d'autres agents thérapeutiques, aux fins de l'inhibition de l'adhésion cellulaire, du traitement de troubles angiogéniques, d'inflammations, de la dégénérescence osseuse, de la métastase cancéreuse, de la rétinopathie diabétique, de la thrombose, de la resténose, de la dégénérescence maculaire et d'autres états pathologiques provoqués par une adhésion cellulaire et/ou une migration cellulaire et/ou l'angiogenèse.

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