C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 405/06 (2006.01) A61K 31/443 (2006.01) A61P 9/00 (2006.01) A61P 11/00 (2006.01) A61P 25/00 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2666903
Multiple stereoisomers of the heterocyclic-substituted tricyclics of the formula: or a pharmaceutically acceptable salt, solvate, or ester of said compound wherein R and the stereochemistry are illustrated in the structural formulas herein are disclosed, as well as pharmaceutical compositions containing them and a method of treating diseases associated with thrombosis, atherosclerosis, restenosis, hypertension, angina pectoris, arrhythmia, heart failure, and cancer by administering said compounds. Combination therapy with other cardiovascular agents is also claimed.
L'invention concerne plusieurs stéréoisomères des composés tricycliques à substitution hétérocyclique de formule I, ou un sel, solvate ou ester pharmaceutiquement acceptable dudit composé, où R et la stéréochimie sont représentés dans les formules structurelles telles que décrites dans l'invention, ainsi que des compositions pharmaceutiques les renfermant et un procédé de traitement des maladies associé à la thrombose, à l'athérosclérose, la resténose, l'hypertension, l'angine de poitrine, l'arythmie, l'insuffisance cardiaque et le cancer par administration desdits composés. La présente invention concerne également une polythérapie avec d'autres agents cardiovasculaires.
Chackalamannil Samuel
Li Tao
Thiruvengadam Tiruvettipuram K.
Wang Yuguang
Zavialov Ilia A.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Schering Corporation
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