Heteroaryl substituted pyrroles useful as inhibitors of...

C - Chemistry – Metallurgy – 07 – D

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C07D 403/04 (2006.01) A61K 31/4025 (2006.01) A61P 35/00 (2006.01) C07D 401/14 (2006.01) C07D 487/04 (2006.01)

Patent

CA 2515132

The present invention provides compounds that are inhibitors of protein kinase, particularly inhibitors of ERK2, GSK3, PKA, CDK2 protein kinases, mammalian protein kinases involved in proliferative and neurodegenerative disorders. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of utilizing those compositions in the treatment of various disorders.

La présente invention concerne des composés servant d'inhibiteurs de protéines kinases, en particulier d'inhibiteurs de protéines kinases ERK2, GSK3, PKA, CDK2, et de protéines kinases mammifères impliquées dans des troubles prolifératifs et neurodégénératifs. L'invention concerne également des compositions pharmaceutiques contenant les composés selon l'invention, et des procédés d'utilisation de ces compositions dans le traitement de divers troubles.

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