Adenovirus fiber shaft composition and methods of use

Details Adenovirus fiber shaft composition and methods of use Adenovirus fiber shaft composition and methods of use

C - Chemistry, Metallurgy

12

N

C12N 15/86 (2006.01)

Patent

CA 2584639

The invention provides a gene transfer vector and a conjugate comprising at least three contiguous amino acids of a shaft region of a subgroup C adenovirus fiber protein. The invention also provides methods of using the gene transfer vector and the conjugate to induce an immune response in a mammal, and to deliver a protein or a non-proteinaceous molecule to a specific cell type.

L'invention concerne un vecteur de transfert de gènes et un conjugué comprenant au moins trois acides aminés adjacents d'une tige de protéine fibreuse d'adénovirus du sous-groupe C. L'invention concerne également des méthodes d'utilisation du vecteur de transfert de gènes et du conjugué pour induire une réponse immune chez un mammifère, et pour distribuer une protéine ou une molécule non protéique à un type de cellule spécifique.

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