Inhibitors of integrin .alpha.v.beta.6

Details Inhibitors of integrin .alpha.v.beta.6 Inhibitors of integrin .alpha.v.beta.6

C - Chemistry, Metallurgy

07

C

C07C 275/16 (2006.01) A61K 31/17 (2006.01) A61K 31/27 (2006.01) A61P 7/00 (2006.01) A61P 9/00 (2006.01) A61P 13/00 (2006.01) A61P 15/00 (2006.01) A61P 19/00 (2006.01) A61P 25/00 (2006.01) A61P 27/00 (2006.01) A61P 31/00 (2006.01) A61P 33/00 (2006.01) A61P 35/00 (2006.01) A61P 43/00 (2006.01) C07C 271/22 (2006.01) C07C 275/18 (2006.01) C07C 275/20 (2006.01) C07C 275/24 (2006.01) C07C 275/26 (2006.01) C07C 275/28 (2006.01) C07C 275/30 (2006.01) C07C 275/34 (2006.01) C07C 335/08 (2006.01) C07C 335/12 (2006.01)

Patent

CA 2444247

The invention relates to the novel biphenyl derivatives of the general formula (I), wherein R1, R1', R1'', R2 and n are defined as in claim 1. The invention also relates to the stereoisomers and the physiologically acceptable salts or solvates thereof which represent novel integrin ligands, especially of the .alpha.v.beta.6 integrin receptor. The novel compounds are suitable for use as medicaments.

L'invention concerne de nouveaux dérivés de biphényle correspondant à la formule générale (I), dans laquelle R?1¿, R?1'¿, R?1''¿, R?2¿ et n correspondent aux définitions données dans la revendication 1, ainsi que leurs stéréoisomères et leurs sels ou solvates physiologiquement acceptables, lesquels sont de nouveaux ligands de l'intégrine, en particulier du récepteur d'intégrine .alpha.¿V?.beta.¿6?. Ces nouveaux composés peuvent être utilisés comme médicaments.

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