Heterocyclic compounds as inhibitors of rotamase enzymes

Details Heterocyclic compounds as inhibitors of rotamase enzymes Heterocyclic compounds as inhibitors of rotamase enzymes

C - Chemistry, Metallurgy

07

D

C07D 413/14 (2006.01) A61K 31/445 (2006.01) C07D 207/16 (2006.01) C07D 211/40 (2006.01) C07D 211/60 (2006.01) C07D 401/04 (2006.01) C07D 413/04 (2006.01) C07D 417/04 (2006.01)

Patent

CA 2322442

Compounds of formula (I) wherein R1, Y, W, A and R2 as defined above are inhibitors of rotamase enzymes in particular FKBP-12 and FKBP-52. The compounds therefore moderate neuronal regeneration and outgrowth and can be used for treating neurological disorders arising from neurodegenerative diseases and nerve damage.

Cette invention concerne des composés de formule (I) qui sont des inhibiteurs des enzymes rotamases et plus particulièrement de FKBP-12 et de FKPB-52. Dans la formule (I) R?1¿, Y, W, A et R?2¿ sont tels que définis ci-dessous. Ces composés modèrent par conséquent la régénération neuronale et la croissance anarchique des neurones et peuvent être utilisés pour traiter des troubles neurologiques provoqués par des maladies neurodégénératives et des atteintes nerveuses.

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