Phenanthridinones as parp inhibitors

Details Phenanthridinones as parp inhibitors Phenanthridinones as parp inhibitors

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/473 (2006.01) A61P 9/00 (2006.01) A61P 25/00 (2006.01) C07D 209/00 (2006.01) C07D 221/00 (2006.01) C07D 221/12 (2006.01) C07D 231/00 (2006.01) C07D 235/00 (2006.01) C07D 401/04 (2006.01) C07D 401/06 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 409/14 (2006.01) C07D 487/04 (2006.01)

Patent

CA 2480384

A compound of the formula (I):whereinring A is a carbocyclic group, R1 is hydrogen or a halogen atom or a lower alkyl group,R2 is a di(lower)alkylamino group or N-containing heterocyclic group, among which the N-containing heterocyclic group may be substituted with one or more substituent(s),Y is an oxygen or sulfur atom, n is an integer from 0 to 2, andm is an integer from 0 to 4,or its prodrug, or their salt.which has poly(adenosine 5'-diphospho- ribose)polymerase inhibiting activity.

La présente invention concerne un composé représenté par la formule (I). Dans cette formule A est un groupe carbocyclique, R1 est hydrogène, un atome halogène ou un groupe alkyle inférieur, R2 est un groupe dialkylamino (inférieur) ou un groupe hétérocyclique contenant N, ce groupe hétérocyclique contenant N pouvant être substitué par un ou plusieurs substituants, Y est un atome d'oxygène ou de soufre, n est un entier compris entre 0 et 2 et m est un entier compris entre 0 et 4. Ce composé peut être constitué d'une prodrogue ou d'un sel de celui-ci. Il possède une activité inhibitrice de poly(adénosine 5'-diphospho-ribose)polymérase.

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