Novel cell signaling polypeptides and nucleic acids

Details Novel cell signaling polypeptides and nucleic acids Novel cell signaling polypeptides and nucleic acids

C - Chemistry, Metallurgy

12

N

C12N 15/54 (2006.01) C07K 14/47 (2006.01) C07K 16/40 (2006.01) C07K 19/00 (2006.01) C12N 5/10 (2006.01) C12N 9/12 (2006.01) C12N 15/12 (2006.01) C12N 15/85 (2006.01) C12Q 1/48 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2347653

The present invention relates to an isolated SRK polypeptide, biologically- active polypeptide fragments thereof, and nucleic acids which code for it. This polypeptide has various activities in regulating cell signaling and signal transduction pathways, including, e.g., a protein kinase activity; an autophosphorylating activity; a cell survival promoting activity; a HAX-1 binding activity; an apoptosis suppression activity; a MAPKK stimulatory activity; a transcription modulatory activity, and a SRK-specific immunogenic activity. The invention relates to all aspects of SRK, or homologs thereof, including assays for modulators, activators, ligands, etc. The invention also relates to a cytolic or soluble HAX-1 which produces apoptosis when expressed in cells.

L'invention concerne un polypeptide de SRK isolé, des fragments polypeptidiques de ceux-ci, actifs au plan biologique, et des acides nucléiques codant pour ledit polypeptide. Ledit polypeptide présente différentes activités de régulation de la signalisation cellulaire et de voies de transduction de signal, dont, par exemple, une activité de protéine kinase; une activité d'autophosphorylation; une activité favorisant la survie cellulaire; une activité de fixation d'HAX-1; une activité de suppression de l'apoptose; une activité de stimulatrice de MAPKK; une activité de modulation de transcription, et une activité immunogène spécifique de SRK. L'invention porte également sur tous les aspects de SRK, ou d'homologues de celui-ci, ainsi que sur des analyses de modulateurs, d'activateurs, de ligands etc. Elle se rapporte encore à un HAX-1 cytolique ou soluble qui produit l'apoptose lorsqu'il est exprimé dans des cellules.

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