A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/00 (2006.01) A61K 9/16 (2006.01) A61K 9/20 (2006.01) A61K 9/50 (2006.01) A61K 47/48 (2006.01)
Patent
CA 2624494
The invention concerns coated granules comprising (A) at least one amine-containing pharmacological active principle, preferably as an acid addition salt, said pharmacological active principle being complexed by low cation-exchange resin comprising carboxylic acid groups (COO"), and (B) at least 15 wt. %, based on the total weight of the active principle/low cation-exchange resin complex, of at least one hydrophilic adsorbent, the mixture of said components (A) and (B) being coated with a gastrosoluble polymer. The invention also concerns a method for preparing such granules, as well as orodispesible tablets containing such granules.
La présente invention concerne des granulés enrobés comprenant (A) au moins un principe actif pharmacologique aminé, de préférence sous forme de sel d'addition d'acide, ledit principe actif pharmacologique étant complexé par une résine échangeuse de cations faible comportant des groupes acide carboxylique (COO"), et (B) au moins 15 % en poids, rapporté au poids total du complexe principe actif/résine échangeuse de cations faible, d'au moins un adsorbant hydrophile, le mélange des composants (A) et (B) étant enrobé par un polymère gastrosoluble, un procédé de préparation de tels granulés, ainsi que des comprimés orodispersibles contenant de tels granulés .
Chaudhari Mahendra B.
Gendrot Edouard
Ethypharm
Gowling Lafleur Henderson Llp
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