Rna antagonists targeting gli2

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/11 (2006.01) A61K 31/7088 (2006.01)

Patent

CA 2730641

The present invention relates to oligomer compounds (oligomers), which target GLI2 mRNA in a cell, leading to reduced expression of GLI2. Reduction of GLI2 expression is beneficial for the treatment of certain medical disorders, such as hy-perproliferative disorders, such as cancer.

La présente invention porte sur des composés oligomères (oligomères) qui ciblent l'ARNm de GLI2 dans une cellule, conduisant à une expression réduite de GLI2. Une réduction de l'expression de GLI2 est avantageuse pour le traitement de certains troubles médicaux, tels que les troubles hyperprolifératifs comme le cancer.

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