Immunochemically equivalent hiv drug analogs

Details Immunochemically equivalent hiv drug analogs Immunochemically equivalent hiv drug analogs

C - Chemistry, Metallurgy

07

D

C07D 213/42 (2006.01) A61K 31/513 (2006.01) A61K 31/536 (2006.01) A61P 31/18 (2006.01) C07D 239/10 (2006.01) C07D 265/18 (2006.01) C07K 16/38 (2006.01)

Patent

CA 2664430

HIV protease inhibitor analogs and non-nucleoside reverse transcriptase inhibitor analogs are provided that are immunochemically equivalent to the parent compound. These analog compounds are useful as calibrators and positive controls in assays for determining HIV protease inhibitors and non-nucleoside reverse transcriptase inhibitors in samples. Methods for preparing calibration curves using the analogs and test kits comprising the analogs are also provided.

L'invention concerne des analogues d'inhibiteurs de la protéase du VIH et des analogues d'inhibiteurs de la transcriptase inverse non nucléosidique qui sont immunochimiquement équivalents au composé parent. Ces analogues sont utiles comme agents d'étalonnage et comme témoins positifs dans des dosages visant à mesurer des inhibiteurs de la protéase du VIH et des inhibiteurs de la transcriptase inverse non nucléosidique dans des échantillons. L'invention concerne également des procédés de préparation de courbes d'étalonnage à l'aide de ces analogues et des kits d'essai les incorporant.

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