Reproductive cancer diagnosis and therapy

Details Reproductive cancer diagnosis and therapy Reproductive cancer diagnosis and therapy

C - Chemistry, Metallurgy

12

N

C12N 15/18 (2006.01) A61K 39/395 (2006.01) A61K 45/00 (2006.01) A61P 13/00 (2006.01) A61P 15/00 (2006.01) A61P 35/00 (2006.01) C07K 7/08 (2006.01) C07K 14/47 (2006.01) C07K 14/475 (2006.01) C07K 14/60 (2006.01) C07K 14/705 (2006.01) C07K 14/71 (2006.01) C07K 14/72 (2006.01) C07K 16/18 (2006.01) C07K 16/22 (2006.01) C07K 16/28 (2006.01) C07K 16/30 (2006.01) C12N 15/12 (2006.01) C12N 15/63 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2446857

A method of detecting a cancer cell or tissue of the reproductive system such as prostate cancer, breast cancer, ovarian cancer, cervical cancer and uterine cancer uses detection of relatively increased levels of ghrelin, an exon 3- deleted form of preproghrelin and/or growth hormone secretagogue type 1b receptor expression by cancer cells as compared to normal cells and tissues of the reproductive system. Also provided is an exon 3-deleted form of preproghrelin and antibodies thereto as well interventionist strategies that target ghrelin and/or growth hormone secretagogue receptors in treating cancers of the reproductive system such as prostate cancer and breast cancer, although without limitation thereto.

L'invention concerne une méthode de détection d'une cellule cancéreuse ou d'un tissu cancéreux du système reproducteur, par exemple le cancer de la prostate, le cancer du sein, le cancer de l'ovaire, le cancer de l'utérus et le cancer utérin, consistant à détecter des niveaux relativement supérieurs de ghréline, une forme délétée d'exon 3 de préproghréline et/ou l'expression des récepteurs de type 1b des sécrétagogues de l'hormone de croissance par des cellules cancéreuses, par comparaison aux cellules et tissus normaux du système reproducteur. L'invention concerne également une forme délétée d'exon 3 de préproghréline et ses anticorps, ainsi que des procédures interventionnelles ciblant la ghréline et/ou les récepteurs des sécrétagogues de l'hormone de croissance dans le traitement des cancers du système reproducteur tels que, entre autres, le cancer de la prostate et le cancer du sein.

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