Polymerase .delta. mutations in colorectal tumors with...

Details Polymerase .delta. mutations in colorectal tumors with... Polymerase .delta. mutations in colorectal tumors with...

C - Chemistry, Metallurgy

12

N

C12N 15/54 (2006.01) A01K 67/027 (2006.01) A61K 48/00 (2006.01) C12N 9/12 (2006.01) C12Q 1/48 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2209226

The human pol .delta. gene, responsible for a replication error phenotype in some colorectal tumors, can be used for diagnostic and therapeutic purposes. It can be used to demonstrate the existence of germline or somatic mutations in replication error (RER+) tumor cells.

Le gène humain pol .delta., responsable d'un phénotype comportant des erreurs de réplication dans certaines tumeurs colo-rectales, peut servir à des fins diagnostiques et thérapeutiques. Il peut servir à démontrer l'existence de mutations de lignées germinales ou de nature somatique dans des cellules tumorales comportant des erreurs de réplication (RER?+¿).

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