Pyrazole phenyl derivatives as ppar activators

Details Pyrazole phenyl derivatives as ppar activators Pyrazole phenyl derivatives as ppar activators

C - Chemistry, Metallurgy

07

D

C07D 231/12 (2006.01) A61K 31/41 (2006.01) A61P 3/00 (2006.01)

Patent

CA 2563461

This invention is concerned with compounds of the formula (I) wherein one of R5, R6 and R7 is (a) and X1, X2, R1 to R15 and n are as defined in the description, and pharmaceutically acceptable salts and/or esters thereof. The invention further relates to pharmaceutical compositions containing such compounds, to a process for their preparation and to their use for the treatment and/or prevention of diseases which are modulated by PPAR.delta. and/or PPAR.alpha. agonists.

L'invention concerne des composés représentés par la formule (I), dans laquelle l'un des éléments R?5¿, R?6¿ et R?7¿ représente (a) et X?1¿, X?2¿, R?1¿ à R?15¿ et n sont tels que définis dans la description, ainsi que des sels et/ou esters pharmaceutiquement acceptables desdits composés. L'invention concerne également des compositions pharmaceutiques contenant lesdits composés, un procédé pour leur préparation, ainsi que leur utilisation pour le traitement et/ou la prévention de maladies qui sont modulées par des agonistes des PPAR.delta. et/ou des PPAR.alpha..

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