Amino-5- [4- (difluoromethoxy) phenyl] -5-phenylimidazolone...

Details Amino-5- [4- (difluoromethoxy) phenyl] -5-phenylimidazolone... Amino-5- [4- (difluoromethoxy) phenyl] -5-phenylimidazolone...

C - Chemistry, Metallurgy

07

D

C07D 233/88 (2006.01) A61K 31/4168 (2006.01) A61P 25/28 (2006.01)

Patent

CA 2623245

The present invention provides a 2-amino-5-[4-(difluoromethoxy)phenyl]-5-3,5- dihydro-phenylimidazol-4-one compound of formula (I) The present invention also provides methods for the use thereof to inhibit ~-secretase (BACE) and treat ~-amyloid deposits and neurofibrillary tangles.

L'invention concerne un composé de 2-amino-5-[4-(difluorométhoxy)phényl]-5-3,5-dihydro-phénylimidazol-4-one de formule (I). L'invention concerne également des procédés d'utilisation de celui-ci aux fins d'inhibition de la ß-sécrétase (BACE) et de traitement de dépôts ß-amyloïdes et d'enchevêtrements neurofibrillaires.

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