Silinane compounds as cysteine protease inhibitors

Details Silinane compounds as cysteine protease inhibitors Silinane compounds as cysteine protease inhibitors

C - Chemistry, Metallurgy

07

F

C07F 7/08 (2006.01) A61K 45/00 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2554626

The present invention is directed to compounds that are inhibitors of cysteine proteases, in particular, cathepsins B, K, L, F, and S and are therefore useful in treating diseases mediated by these proteases. The present invention is also directed to pharmaceutical compositions comprising these compounds and processes for preparing them. The present invention is also directed to the use of these inhibitors in combination with a therapy that causes a deleterious immune response in patients receiving the therapy.

L'invention concerne des composés qui sont des inhibiteurs de cystéine protéase, en particulier les cathepsines B, K, L, F, et S, et qui sont donc utiles pour le traitement des maladies dont la médiation est assurée par ce type de protéase. L'invention concerne également des compositions pharmaceutiques qui renferment les composés en question, et des procédés d'élaboration correspondants. L'invention concerne enfin l'utilisation des inhibiteurs considérés en combinaison avec une thérapie induisant une réponse immunitaire délétère chez les patients visés.

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