Opsonin-enhanced cells, and methods of modulating an immune...

Details Opsonin-enhanced cells, and methods of modulating an immune... Opsonin-enhanced cells, and methods of modulating an immune...

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) A61K 39/00 (2006.01) C07K 14/47 (2006.01) C07K 19/00 (2006.01) C12N 1/15 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 7/01 (2006.01) C12N 15/12 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2249354

Disclosed are methods and compositions wherein opsonin-enhanced cells, that is, cells which have been 1) modified so as to express an opsonin from a recombinant nucleic acid, 2) modified so as to express higher levels of an endogenous opsonin, or 3) mixed with an exogenous opsonin, when administered to a subject, modulate the immune response in the recipient to a selected antigen or antigens contained in or attached to the cells.

Procédés et compositions faisant appel à des cellules renforcées par opsonine, c'est-à-dire, des cellules qui ont été (1) modifiées de façon à exprimer une opsonine provenant d'un acide nucléique recombinant, (2) modifiées de façon à exprimer des niveaux accrus d'une opsonine endogène, ou (3) mélangées avec une opsonine exogène. Les cellules ainsi modifiées modulent, lorsqu'elles sont administrées à un sujet, la réponse immune du receveur à un antigène ou des antigènes choisis contenus dans ces cellules ou qui y sont fixés.

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