Methods and compositions concerning poxviruses and cancer

Details Methods and compositions concerning poxviruses and cancer Methods and compositions concerning poxviruses and cancer

C - Chemistry, Metallurgy

12

N

C12N 7/01 (2006.01) A61K 9/00 (2006.01) A61K 35/76 (2006.01) A61K 38/21 (2006.01) A61K 38/48 (2006.01) A61K 39/285 (2006.01) A61P 35/00 (2006.01) C12N 7/00 (2006.01) C12Q 1/70 (2006.01) C12N 5/08 (2006.01)

Patent

CA 2494844

The present invention concerns methods and compositions for the treatment of cancer and cancer cells using altered poxviruses, including a vaccinia virus that has been altered to generate a more effective therapeutic agent. Such poxviruses are engineered to be attenuated or weakened in their ability to affect normal cells. In some embodiments, methods and compositions involve poxviruses that possess mutations that result in poxviruses with diminished or eliminated capability to implement an antiviral response in a host. Poxviruses with these mutations in combination with other mutations can be employed for more effective treatment of cancer.

La présente invention concerne des procédés et compositions destinés au traitement du cancer et des cellules cancéreuses au moyen de poxvirus modifiés, y compris le virus de la vaccine, modifiés de façon à produire un agent thérapeutique plus puissant. De tels poxvirus ont été traités par génie génétique de façon à en atténuer ou affaiblir l'aptitude à affecter les cellules normales. Pour certains modes de réalisation, les procédés et compositions ont recours à des poxvirus qui présentent des mutations donnant des poxvirus rendus partiellement ou totalement incapables de mettre en oeuvre une réponse antivirale chez l'hôte. Les poxvirus présentant ces mutations associées à d'autres mutations conviennent pour un traitement plus puissant du cancer.

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