Process for the reductive amination of aldehydes and ketones...

Details Process for the reductive amination of aldehydes and ketones... Process for the reductive amination of aldehydes and ketones...

C - Chemistry, Metallurgy

07

C

C07C 209/26 (2006.01) C07C 211/18 (2006.01)

Patent

CA 2612574

Aldehyde or ketone compounds having more than one carbonyl group are reductively aminated to form a product amine compound having more than one primary amino group. The aldehyde or ketone compound is reacted with the product amine compound, to form a reaction mixture that contains one or more intermediates. The intermediate is then reductively aminated to form the desired product. This process produces the desired product in very high yields with low levels of secondary amine impurities.

L'invention concerne des composés d'aldéhyde ou cétone comprenant plus d'un groupe carbonyle et aminés de manière réductrice aux fins de formation d'un composé d'amine de produit comprenant plus d'un groupe amino principal. Le composé d'aldéhyde ou cétone est mis à réagir avec le composé d'amine de produit, de manière à former un mélange de réaction renfermant un ou plusieurs intermédiaires. L'intermédiaire est ensuite aminé de manière réductrice afin de former le produit souhaité. Ce procédé permet de produire le produit souhaité à des rendements très élevés avec des niveaux faibles d'impuretés d'amine secondaire.

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