C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/30 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) C12N 15/13 (2006.01)
Patent
CA 2633756
The present invention relates to pharmaceutical compositions for the treatment of an epithelial tumor in a human, said pharmaceutical composition comprising an IgG1 antibody specifically binding to human CEA, wherein the variable region of said IgG1 antibody comprises at least (i) a CDR-H1 having the amino acid sequence "SYWMH" and a CDR-H2 having the amino acid sequence "FIRNKANGGTTEYAASVKG" and a CDR-H3 having the amino acid sequence "DRGLRFYFDY" or (ii) a CDR-H 1 having the amino acid sequence "TYAMH" and a CDR-H2 having the amino acid sequence "LISNDGSNKYYADSVKG" and a CDR-H3 having the amino acid sequence "DRGLRFYFDY". Furthermore, processes for the production of said pharmaceutical compositions as well as medical/pharmaceutical uses for the IgG1 antibody molecules bearing specificities for the human CEA antigen are disclosed.
La présente invention concerne des compositions pharmaceutiques pour le traitement d'une tumeur épithéliale chez un humain, ladite composition pharmaceutique comprenant un anticorps IgG1 se liant spécifiquement à CEA humain, la région variable dudit anticorps IgG1 comprenant au moins (i) un CDR-H1 ayant la séquence d'acides aminés "SYWMH" et un CDR-H2 ayant la séquence d'acides aminés "FIRNKANGGTTEYAASVKG" et un CDR-H3 ayant la séquence d'acides aminés "DRGLRFYFDY" ou (ii) un CDR-H1 ayant la séquence d'acides aminés "TYAMH" et un CDR-H2 ayant la séquence d'acides aminés "LISNDGSNKYYADSVKG" et un CDR-H3 ayant la séquence d'acides aminés "DRGLRFYFDY". En outre, la présente invention concerne des procédés pour la production desdites compositions pharmaceutiques ainsi que des utilisations médicales/pharmaceutiques pour les molécules d'anticorps IgG1 comportant des spécificités pour l'antigène CEA humain.
Kufer Peter
Mangold Susanne
Rau Doris
Raum Tobias
Goudreau Gage Dubuc
Micromet Ag
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