2,6-disubstituted quinazolines, quinoxalines, quinolines and...

Details 2,6-disubstituted quinazolines, quinoxalines, quinolines and... 2,6-disubstituted quinazolines, quinoxalines, quinolines and...

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) A61K 31/4709 (2006.01) A61K 31/517 (2006.01) A61P 35/00 (2006.01) A61P 43/00 (2006.01) C07D 401/14 (2006.01) C07D 405/14 (2006.01)

Patent

CA 2542329

New substituted quinazoline, quinoxaline, quinoline and isoquinoline compounds of formulae (I)-(IV), compositions and methods of inhibition of Raf kinase activity in a human or animal subject are provided. The new compounds compositions may be used either alone or in combination with at least one additional agent for the treatment of a Raf kinase mediated disorder, such as cancer. The substituents are defined in the claims.

L'invention concerne de nouveaux composés de quinoxaline, de quinoline, d'isoquinoline et de quinazoline substituée, de formules (I)/(IV). L'invention concerne des compositions et des méthodes d'inhibition de l'activité de la kinase Raf chez un humain ou chez un animal. Les compositions de nouveaux composés peuvent être utilisées soit seules, ou combinées à au moins un agent supplémentaire pour le traitement d'un trouble médié par la kinase Raf, notamment le cancer. Les substituants sont définis dans les revendications.

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