Oil-in-water emulsion of mometasone and propylene glycol

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/09 (2006.01) A61K 9/00 (2006.01) A61K 9/06 (2006.01) A61K 31/573 (2006.01) A61K 31/58 (2006.01) A61K 47/34 (2006.01)

Patent

CA 2761739

Novel pharmaceutical compositions of mometasone or a pharmaceutically acceptable derivate thereof in the form of an oil-in-water emulsion, notably a cream. The composition has excellent stability and therapeutic effect. The compositions contain mometasone in micronised form, propylene glycol and water and the weight ratio between the propylene glycol and water contained in the oil-in-water emulsion is from 1 :1 to about 1 :3.

La présente invention concerne de nouvelles compositions pharmaceutiques de mométasone ou un dérivé pharmaceutiquement acceptable de celle-ci sous la forme d'une émulsion d'huile dans l'eau, notamment une crème. La composition a une stabilité et un effet thérapeutique excellents. Les compositions contiennent de la mométasone sous forme micronisée, du propylène glycol et de l'eau et le rapport en poids entre le propylène glycol et l'eau contenus dans l'émulsion d'huile dans l'eau est de 1:1 à environ 1:3.

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