Methods and compositions for sensitive and rapid, functional...

Details Methods and compositions for sensitive and rapid, functional... Methods and compositions for sensitive and rapid, functional...

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) A01K 67/00 (2006.01) C12N 15/10 (2006.01) C12Q 1/34 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2409901

The invention provides for a methods and compositions for identifying proteins or compounds that directly or indirectly modulate a genomic polynucleotide and methods for identifying active genomic polynucleotides. Generally, the method comprises inserting a BL (beta-lactamase) expression construct into an eukaryotic genome, usually non-yeast, contained in at least one living cell, contacting the cell with a predetermined concentration of a modulator, and detecting BL activity in the cell.

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