Stannous chloride compositions

A - Human Necessities – 61 – K

Patent

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Details

A61K 8/02 (2006.01) A61K 8/04 (2006.01) A61K 8/19 (2006.01) A61K 8/25 (2006.01) A61Q 11/00 (2006.01)

Patent

CA 2726086

The invention relates to a particulate composition comprising: c) a particulate source of stannous chloride; d and silicon dioxide (also referred to as hydrated silica or silica). The invention further relates to a method for improving the flowability of particulate stannous chloride by admixing silica with it. The composition of the invention has been found to give improved flow properties to stannous chloride when compared to the absence of an anti- caking agent, as assessed via methods of powder characterisation detailed in the European Pharmacopoeia.

La présente invention concerne une composition particulaire comprenant : c) une source particulaire de chlorure stanneux ; d) et du dioxyde de silicium (aussi désigné silice hydratée ou silice). Linvention concerne en outre un procédé permettant daméliorer laptitude à sécouler du chlorure stanneux particulaire en le mélangeant avec de la silice. La composition de linvention sest avérée conférer des propriétés découlement améliorées au chlorure stanneux par comparaison avec labsence dun agent anti-agglomérant, comme cela est évalué par des procédés de caractérisation des poudres détaillés dans la pharmacopée européenne.

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