Pyrimidine derivatives and compositions as c-kit and pdgfr...

Details Pyrimidine derivatives and compositions as c-kit and pdgfr... Pyrimidine derivatives and compositions as c-kit and pdgfr...

C - Chemistry, Metallurgy

07

D

C07D 401/14 (2006.01) A61K 31/444 (2006.01) A61P 35/00 (2006.01) C07D 405/14 (2006.01)

Patent

CA 2686378

The invention provides a novel class of pyrimidine derivatives, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of c-kit, PDGFR.alpha. and PDGFR.beta. kinases.

La présente invention concerne une nouvelle classe de dérivés de pyrimidine, des compositions pharmaceutiques contenant de tels composés et des méthodes d'utilisation de ces composés afin de traiter et de prévenir les maladies ou les pathologies associées à une activité kinase anormale ou déréglée, notamment les maladies ou les pathologies qui impliquent une activation anormale des kinases c-kit, PDGFR.alpha. et PDGFR.beta..

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